Isuzu Automobile Co., Ltd. (hereinafter referred to as Isuzu) is a Japanese commercial vehicle and diesel engine manufacturing company headquartered in Tokyo. Its main activities are the production, sale and sale of Isuzu commercial vehicles and diesel engines.

It also has a number of subsidiaries, including Anadolu Isuzu (Turkish joint venture with Anadolu group), solers Isuzu (Russian joint venture with solers JSC), SML Isuzu (Indian joint venture, formerly Swaraj Mazda), Jiangxi Isuzu automobile (a Chinese joint venture with Jiangling Automobile Group), Isuzu Astra Automobile Company Indonesia, Isuzu Malaysia (HICOM), Isuzu UK, Isuzu South Africa, Isuzu Philippines, Isuzu Taiwan, Isuzu Vietnam, Isuzu India and BYD Isuzu.

Isuzu has assembly and manufacturing plants in Fujisawa, the Mu county and Hokkaido county. Isuzu's cars are sold in most of the world's commercial markets. Isuzu's main market focus is on commercial diesel powered trucks, buses and construction, while its Japanese rival, Yangma, focuses on commercial grade power plants and generators.

By 2009, Isuzu had produced more than 21 million diesel engines, found in cars around the world. Isuzu diesel engines are used by dozens of automakers, including general motors.

The name Isuzu has been translated into English "Isuzu".

In most parts of Asia and Africa, Isuzu is mainly known for trucks of all sizes, as sales of Isuzu small cars fell sharply, and Isuzu had to give up all sales of cars and compact cars in the late 1990s. In the era of Isuzu selling passenger cars, they are famous for their niche market focusing on diesel engines. For example, in 1983, before the explosion in diesel sales, diesel accounted for 63.4% of passenger car production. [28] in 2009, Isuzu abandoned the U.S. consumer market due to insufficient sales. Isuzu, as a company, has always been a manufacturer of small and medium-sized compact cars and medium and larger commercial trucks, but the global market shows different needs.

Isuzu Motor USA stopped selling passenger cars in the United States from January 31, 2009. The company explained to dealers that it was unable to ensure commercially viable alternatives to the Isuzu ascender and Isuzu I series. Isuzu sold 7098 cars in 2007. The move did not affect Isuzu's commercial or industrial diesel engine business in the United States. Isuzu has signed a contract with budget truck rental to manufacture trucks and share them with Ford, GMC and Navistar international.

In Australia, Isuzu has been a major supplier of light commercial and household vehicles to Holden (General Motors) for many years. However, by 2008, Houghton had barely purchased isuzus. At this time, Isuzu began to sell D-max under the name of Isuzu.

Isuzu's entry into the Thai market has proved to be one of its most successful. Its operations in the country began in 1966, when it established a light truck manufacturing plant in samuthprakarn province with an annual capacity of 155000 vehicles. The carmaker quickly became a market leader, so by 2002 it had moved its production base from its original location in Fuji, Japan, to Thailand. Isuzu has the largest share of the commercial vehicle market in Thailand, leading its competitors for at least 23 consecutive years. By 2006, the company had moved to an industrial area in chacheongsao province to support further production expansion. By 2017, Isuzu had been exporting pickup trucks, with freight volume reaching North America, Latin America, Australia and Japan. In the same year, it announced a 7% increase in profits and doubled annual production of trucks to meet overseas demand.